The South American religion covers the various pagan religions of the South American native tribes outside the Andean region.
In the game, the South American religion exists throughout the entire timeline, from the very beginning Pre-Roman-Parthian War period (February 2AD-January 58AD) to the Present Day, surviving in the Amazonian jungles of 
Brazil, the plains of 
Northern Paraguay, and (unintentionally) in the Brazilian province of Guayra.
Tupiniquim can rise up in the Present Day with the South American religion if it secedes from Brazil, making it the last pre-Columbian, non-Christian Native American country, which allows for a potential (although difficult) revival of theSouth American religion (and its heresies through events) in the hands of a skilled player. The other two surviving Native American nations (which are both Christian) in the Present Day that can potentially be played are the 
Navajo (from the 
United States) and the 
Cree (from 
Canada) since they can revolt due to their culture surviving in certain provinces.
See also: 
Inti, 
Totemist, Tupiniquim, Brazil, Paraguay, 
Guarani, 
Carib, 
Arawak
Bonuses
+5% National Tax Modifier- +1 Tolerance of the True Faith
Negatives
- +2% Local Missionary Strength (South American provinces are easier to convert).
- Permanently nerfed with the removal of the personal deities.
Mechanics
South American is in the Native American group, and has four heretics: 
Nahuatl, 
Mayan, Inti, and Totemist. In previous patches, the South American religion used to have personal deities, but has not since early 2015 with the release of the fifth major DLC, 
El Dorado.